Candidate long-range regulatory sites acting on the IL17 pathway genes TRAF3IP2 and IL17RA are associated with psoriasis
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چکیده
منابع مشابه
Genetic epistasis of IL23/IL17 pathway genes in Crohn's disease.
BACKGROUND The IL23/IL17 pathway is pivotal in the development of chronic mucosal inflammation seen in Crohn's disease (CD). Genetic variants in the IL23R and IL12B have been associated with CD susceptibility. We investigated 10 genes within the IL23/IL17 pathway in a case-control study of 763 CD cases and 254 healthy controls. METHODS We identified a novel association in haplotypes in IL17A ...
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INTRODUCTION Lumbar disc degeneration (LDD) is genetically determined and severity of LDD is associated with Modic changes. Aggrecan is a major proteoglycan in the intervertebral disc and end plate. Progressive reduction of aggrecan is a main feature of LDD and Modic changes. OBJECTIVES The study investigated the associations of single nucleotide variants (SNVs) of candidate genes in the aggr...
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The extended duration of bronchodilation due to formoterol and salmeterol greatly exceeds that of short acting beta 2-adrenoceptor agonists, such as salbutamol or terbutaline. This extended duration and their capacity to "reassert" airway smooth muscle relaxation in vitro despite repeated washing has prompted considerable debate on the underlying mechanism(s). The comparative pharmacology, and ...
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The hippocampus is critical for a wide range of emotional and cognitive behaviors. Here, we performed the first genome-wide search for genes influencing hippocampal oscillations. We measured local field potentials (LFPs) using 64-channel multi-electrode arrays in acute hippocampal slices of 29 BXD recombinant inbred mouse strains. Spontaneous activity and carbachol-induced fast network oscillat...
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The economic efficiency of swine operations is always a topic of discussion for pork producers and allied industries especially now when feed grain prices are being pushed higher as the demand for bio-fuels increases. However, many factors outside of feed prices influence the breakeven costs and thus economic efficiency for swine operations. Of those additional factors, sow herd performance is ...
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ژورنال
عنوان ژورنال: Experimental Dermatology
سال: 2018
ISSN: 0906-6705
DOI: 10.1111/exd.13761